CiviCRM looks like a great constituent relationship management which when matched with Drupal (which I use at UniversalistChurch.net) becomes CivicSpace, the Internet legacy of the Howard Dean campaign. Wikipedia uses it to raise money; that's what sold me on it and I hope to learn it asap.
Indeed, I want to do something that could use it. What a powerful tool.
Look at the 2006 year end report to get inspired.